Single-cell MALDI mass spectrometry (MS) imaging resolution is currently limited by the size of laser spot diameter, matrix crystal size/homogeneity, displacement of analytes during matrix deposition, ...

Mass spectrometry and imaging techniques have emerged as indispensable tools in modern biomedical and chemical research. These integrated methods offer the ability to detect and spatially map ...

For biologists, seeing is believing. But sometimes biologists have a hard time seeing. One particularly vexing challenge is seeing all the molecules in an intact tissue sample, down to the level of ...

A new tissue expansion method enables scientists to use mass spectrometry imaging to simultaneously detect hundreds of molecules at the single cell level in their native locations. For biologists, ...

A molecular image showing the major components of a spinal column. Cells are colored in yellow (grey matter), blue (white matter), teal (fluid), green (blood vessel), pink (bone/bone marrow) and red ...

Spatial proteomics is the study of the spatial distribution of the proteins within cells and tissues. The subcellular localization of proteins is intrinsic to cellular function, making spatial ...

Osaka, Japan – Tissues consist of a heterogenous mixture of different cell types, complicating our understanding of their biological functions and studies of disease. Now, a multi-institutional team ...

Accurately distinguishing renal cell carcinoma (RCC) from normal kidney tissue is critical for identifying positive surgical margins (PSMs) during partial and radical nephrectomy, which remains the ...

Diagnosing cancer and selecting the appropriate therapy depend crucially on how well experts understand the processes in tumors at the microscopic level. Central to this is understanding how cells in ...