Some sequences in the genome cause genes to be switched on or off. Until now, each of these gene switches, or so-called enhancers, was thought to have its own place on the DNA. Different enhancers are ...

TS gene promoter possesses regulatory tandemly repeated (TR) sequences that are polymorphic in humans, depending on ethnic factors. These polymorphisms have been reported to influence TS expression.

Some sequences in the genome cause genes to be switched on or off. Until now, each of these gene switches, or so-called enhancers, was thought to have its own place on the DNA. Different enhancers are ...

A comprehensive analysis has identified novel enhancers associated with neuronal development and disease. An international collaboration of researchers led by Masahito Yoshihara at Chiba University ...

During embryonic development, cells start out as pluripotent, or have the potential to become many different cell types through differentiation. Naive-state is the name for the earliest stage of ...

For stem cells to differentiate into the appropriate cell-type, transcription factors (TFs) must be tailored to highly specific expression patterns of lineage-specific genes. Abnormalities in the ...

Post-mortem examination of a mouse heart shows a clear delineation in blue where TREE gene enhancer sensed and responded to tissue damage of a heart attack. photo - Ken Poss Lab, Duke University ...

Despite spanning about three billion base pairs, the human genome is wrapped up tight in a highly organized fashion in the nucleus. This coordinated structure, in part, enables the cell to regulate ...