The placebo-controlled, double-blind, randomised Phase I trial involved 100 healthy participants.

Scientists have found a way to fine-tune a central fat-control pathway in the liver, reducing harmful blood triglycerides ...

Preclinical and Phase 1 study published in Nature Medicine describes clinical and mechanistic validation for OrsoBio's LXR ...

When eating, the body converts extra calories, especially from carbs, sugar, fats, and alcohol, into triglycerides.

Researchers developed TLC-2716, a liver- and gut-targeted drug that selectively reduced LXR activity, lowering triglycerides, ...

Mutations in LXRα lead to liver cholesterol buildup, hepatitis, and fibrosis in individuals on a Western diet, highlighting the receptor's role in maintaining liver health. Study: Damaging mutations ...

Asharq Al Awsat A study led by researchers from the Ecole Polytechnique Fédérale de Lausanne (EPFL) in Switzerland, revealed ...

A selective Liver X Receptor inverse agonist lowered triglycerides and post-meal cholesterol in people, opening a safer path ...

Liver X receptors (LXRs) are nuclear receptors that function as intracellular cholesterol sensors, orchestrating a complex network of genes involved in lipid metabolism, cholesterol homeostasis and ...