Kickoff is at noon ET from Williams-Brice Stadium. The Gamecocks are 2.5-point favorites in the latest South Carolina vs. Clemson odds, while the over/under is 46.5. Before making any Clemson vs. South Carolina picks, check out the college football predictions from the SportsLine Projection Model .

As South Carolina tries to contain its measles outbreak, public health officials across the nation are concerned that the highly contagious virus is making a major comeback.

Sellers faces a decision that could have a significant impact on the '26 draft and next season's college football landscape.