Observations that diabetics treated with biguanide drugs have a reduced risk of developing cancer have prompted an enthusiasm for these agents as anti-cancer therapies. We sought to determine the ...

A new review article published in the journal Trends in Cancer is presenting a promising case for phenformin, an old diabetes drug related to metformin, being repurposed as an adjunct to new ...

The anti-diabetic drug phenformin may prompt stronger cancer-fighting activities than its sister compound metformin, a finding that could have major implications for current and future clinical trials ...

DURING the past five years phenethylbiguanide, more commonly known as phenformin or DBI, has proved to be a potent hypoglycemic agent. 1 Its main use has been in the control of maturity-onset diabetes ...

LA JOLLA, CA—Ever since discovering a decade ago that a gene altered in lung cancer regulated an enzyme used in therapies against diabetes, Reuben Shaw has wondered if drugs originally designed to ...

A phase 1b trial of PI3K inhibitor copanlisib (BAY 80-6946) combined with the allosteric-MEK inhibitor refametinib (BAY 86-9766) in patients with advanced cancer.

BOSTON - The anti-diabetic drug phenformin may prompt stronger cancer-fighting activities than its sister compound metformin, a finding that could have major implications for current and future ...

Researchers from the University of Dundee have shown that a drug previously used to treat Type II diabetes could potentially be used to protect against cancer. A study carried out by Professors ...

(MENAFN- GlobeNewsWire - Nasdaq) Dublin, March 26, 2025 (GLOBE NEWSWIRE) -- The "Phenformin (CAS 114-86-3) Industry Research 2025: Global and Regional Market Trends 2019-2024 and Forecast to 2029" ...

Preclinical research shows that the combination of two existing drugs can exploit the metabolic'hunger' of a particularly aggressive type of neuroblastoma to kill cancer cells without inflicting too ...

Metformin and phenformin both inhibit mitochondria; however, phenformin is nearly 50 times as potent as metformin. In the study, the researchers tested phenformin as a chemotherapy agent in ...