Onstage in front of 800 people, Anne-Laure Le Cunff realized her worst public-speaking fear. But she rose to the occasion, and taught a major lesson in the process.

Thirty years into the opioid crisis, we still struggle to find other options for pain relief. This hour, TED speakers explain new understandings of how the brain interprets pain and new ideas to cope.

In this illuminating TED Intersections conversation, a neuroscientist and a global financial CEO explore one of humanity’s ...