Cancer Res (2024) 84 (7_Supplement): CT009. Background: Treatment (tx) for LA SCCHN includes a combination of surgery, radiation and/or chemotherapy followed by monitoring for local recurrence/distant ...

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Abstract. MTAP deletions occur in 10-15% of all human cancers, providing one of the largest precision oncology patient populations. MTA-cooperative PRMT5 inhibitors leverage the well-characterized ...

Cancer Res (2023) 83 (7_Supplement): 1143.

Background: LIV-1, also known as SLC39A6 or ZIP6, is a transmembrane protein belonging to the zinc transporter family. LIV-1 is a promising target for antibody-drug conjugate (ADC) therapy due to its ...

Background: SHR-A1921 is a novel ADC composed of a humanized anti-trophoblast cell-surface antigen 2 (TROP-2) IgG1 monoclonal antibody attached to a DNA topoisomerase I inhibitor via a ...

Spencer Mirabile-Brightman, Bjoern Peters, Himangshu Sonowal, Zachary Berman, Zev Wainberg, Aaron Miller, Karen Messer, Jiayu Chen, Yago Pico de Coana, Peter Ellmark, Stephen Schoenberger, Rebekah R.

Cancer Res (2025) 85 (8_Supplement_2): CT221. Patients with stage II colon cancer not classified as high risk (pT4 microsatellite stable) do not receive adjuvant chemotherapy (ACT) according to Dutch ...

Tertiary lymphoid structures (TLS) are organized immune cell aggregates that assemble within tumors and function as local antitumor immune hubs. Although TLSs have emerged as promising biomarkers of ...

Background: FAP is a membrane-bound protease under investigation as a pan-cancer target given its limited expression in normal adult tissues but high expression on cancer-associated fibroblasts.

Background: MM remains incurable and new tx options are needed, especially in heavily pre-treated R/R pts. REGN5459, a BCMAxCD3 bispecific Ab, binds to BCMA on MM cells and with low affinity to CD3 on ...

Cancer Res (2022) 82 (12_Supplement): LB550. Pancreatic cancer is a leading cause of cancer-related deaths worldwide with increasing incidence. Early diagnosis of pancreatic cancer is a key challenge, ...