Gene expression and pathway analysis constitute a critical nexus in modern molecular biology, facilitating the exploration of how genes collectively influence cellular functions and disease processes.

Gene expression analysis and RNA sequencing have transformed our understanding of molecular biology, offering a comprehensive view of transcriptomic landscapes in diverse biological systems. By ...

R-loops are structures that form when a strand of RNA (red) forms a stable structure with double-stranded DNA, causing one strand of the DNA to form a loop. R-loops are associated with gene ...

Researchers at the Jackson Laboratory (JAX), the Broad Institute of MIT and Harvard, and Yale University, have used artificial intelligence (AI) to design thousands of new DNA switches that can ...

The introduction of real-time quantitative PCR (qPCR) in the early 1990s opened the door for quantitative gene expression analysis. Still, qPCR depends on standard curves, allowing only relative ...

Typical workflow of computational cell lineage tracing. The workflow includes cell labeling, data acquisition, trajectory inference, and lineage reconstruction and visualization. Over the past two ...

DNA stores the body’s operating playbook. Some genes encode proteins. Other sections change a cell’s behavior by regulating which genes are turned on or off. For yet others, the dark matter of the ...

Researchers at the Weill Institute for Cell and Molecular Biology have uncovered new evidence that two major types of gene-controlling DNA sequences, promoters and enhancers, operate with a shared ...

Studying gene expression in a cancer patient's cells can help clinical biologists understand the cancer's origin and predict the success of different treatments. But cells are complex and contain many ...

Outcomes of young-onset colorectal cancer vs late-onset colorectal cancer patients on phase 1 matched and non-matched therapies. This is an ASCO Meeting Abstract from the 2025 ASCO Annual Meeting I.

This study presents a valuable finding on the mutational order for common alterations in colorectal cancer. The evidence of in vitro growth assays comparing mutations is solid, although inclusion of ...