The Israel Defense Forces (IDF) said the Damascus headquarters served as a command center for deploying regime forces to Suwayda, a southern Syrian region gripped by days of deadly clashes between government troops, Druze militias, and Bedouin groups.

Israel launched powerful airstrikes in Damascus on Wednesday, blowing up part of the defence ministry and hitting near the presidential palace as it vowed to destroy government forces attacking Druze in southern Syria and demanded they withdraw.

"If Israel feels that a certain leader...is an evident threat to its national security, it will operate," a former Israeli envoy told Newsweek.

Israel’s demand for a demilitarized zone in southern Syria and its promise to protect the Druze minority are putting it in deepening conflict with the new regime in Damascus.

Secretary of State Marco Rubio says IDF strike on Damascus ‘likely a misunderstanding’ after fighting erupted in Syria.