The NEURL E3 ubiquitin ligases selectively activate the Notch ligands DLL1 and JAG1, but not DLL4 and JAG2. This differential ...
DnaK/DnaJ or Trigger factor and find that chaperone dependence during primary biogenesis in vivo does not track with ...
Amplified by social media, the overwhelmingly positive balance between population benefit and individual damage is forgotten. This has been the case for Covid vaccinations, where politics and health ...
Selective autophagy ensures the targeted degradation of damaged or surplus cellular components, including organelles, thereby ...
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Atherosclerosis is characterized by the ...
Centrioles are evolutionarily conserved barrels of microtubule triplets that form the core of the centrosome and the base of the cilium. While the crucial role of the proximal region in centriole ...
Insertion of strongly hydrophobic TMDs into the ER membrane is mediated by the Sec61 complex for co‐translational insertion and the GET complex for post‐translational insertion of tail‐anchors ...
Proteins are the key molecular machines that orchestrate all biological processes of the cell. Most proteins fold into three-dimensional shapes that are critical for their function. Studying the 3D ...
ER–mitochondria contact sites (ERMCSs) regulate processes, including calcium homoeostasis, energy metabolism and autophagy. Previously, it was shown that during growth factor signalling, mTORC2/Akt ...
The GGTase‐III discovery finds its origins in the genome project, where a new protein with prenyl‐transferase homology, namely prenyl‐transferase alpha subunit repeat‐containing 1 (PTAR1), was ...
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