Insulin resistance is concomitant with type 2 diabetes, obesity, hypertension, and other features of the metabolic syndrome. Because insulin resistance is associated with cardiovascular disease, both ...

People with diabetes who depend on insulin face a sharply higher chance of developing dementia than those managing the ...

Insulin resistance precedes and predicts the onset of type 2 diabetes mellitus (DM2), a chronic disease that causes high morbidity and mortality worldwide. In affected people, insulin is unable to ...

Insulin metabolism encompasses the synthesis of proinsulin in pancreatic β-cells, its processing into mature hormone and C-peptide, and regulated release in response to glucose and incretin signals.

Recent research published in the journal Diabetes sheds new light on the cellular mechanisms causing insulin resistance in type 2 diabetes, a disease affecting more than 1.2 million people in Quebec ...

Research from the Max Planck Florida Institute for Neuroscience has identified a mechanism through which insulin-like growth factors facilitate brain plasticity. The insulin superfamily of hormones, ...

Insulin orchestrates systemic glucose homoeostasis by engaging a cell-surface tyrosine kinase receptor and activating a network of intracellular pathways. Upon insulin binding, the insulin receptor ...

Insulin resistance precedes and predicts the onset of type 2 diabetes mellitus (DM2), a chronic disease that causes high morbidity and mortality worldwide. In affected people, insulin is unable to ...

Insulin-producing β-islet cells in the pancreas can be made aware of a lack of insulin in the blood in a diabetes model, through signals relayed by a soluble signaling molecule called T-cadherin, ...

Insulin under normal circumstances exerts its antiatherogenic action in endothelial cells and VSMCs via the PI 3-kinase signaling pathway. Antiatherogenic aspects of insulin action include stimulation ...

A new study focuses on the insulin receptor to understand its role in the development of type 2 diabetes mellitus, a metabolic disease with a major impact on global health. Insulin resistance precedes ...