The Beta Cell Aging Lab aims to understand the contribution of cellular aging to diabetes in animal and human models of disease to find new therapeutic targets that can reverse …

The Aguayo-Mazzucato Lab is interested in studying the aging process of pancreatic beta cells and how it contributes to the development of diabetes. Additionally, we are interested in …

In addition, molecular changes induced by age are explored as potential new targets to preserve and enhance beta cell function during ageing and senescence, which represents a new way to …

Sep 24, 2025 · She became an independent investigator in 2019 and her laboratory at Joslin Diabetes Center focuses on understanding the role of beta cell aging, senescence in …

Aug 1, 2022 · We were originally interested in this topic because age is one of the main risk factors to develop type 2 diabetes, and previous research from the lab showed that the …

Beta cells progress through different life stages, and, with age, the older subpopulation of cells becomes enriched. This enrichment has led us to identify specific markers of beta cell aging …

In July 2019 she established the Beta Cell Aging Lab at Joslin Diabetes Center which aims to understand the molecular progression of senescence and identify alleviating strategies that …

Oct 7, 2022 · To understand the impact of aging on beta cells, we performed meta-analysis of single-cell RNA sequencing datasets, transcription factor (TF) regulon analysis, high …

The scientists identified several markers of aging beta cells, including one protein called IGF1R that is an important player in cell survival. The markers highlighted the striking diversity of beta …

The Beta Cell Aging Lab aims to understand the aging process, and senescence in particular, of insulin-secreting beta cells and how this process contributes to the development of Type 1 and …